NON-INVASIVE EXPLORATION
Le service propose un large panel de modalités d’imagerie de haute technologie dédiées à l’exploration non-invasive de l’animal de laboratoire. Le suivi longitudinal par imagerie implique le maintien du statut sanitaire des animaux tout au long de l’exploration.
EXPLORATION NON-INVASIVE CREFRE
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NON-INVASIVE EXPLORATION

Multi-modal imaging dedicated to the non-invasive exploration of small animals.

Possibility of longitudinal monitoring with maintenance of animal health status.

Expertise

The department is composed of engineers with expertise in molecular imaging and data analysis, a researcher specializing in MRI, and a technician specialized in animal experimentation.

Specificity

Maintenance of the SPF health status of rodents entrusted to the department (all procedures) is ensured by the use of containment cells adapted for MRI, PET, SPECT and CT procedures.

Services

Scientific collaborations, research and development, and service delivery. The department is open to both academics and private companies. Participation in regulatory (UPAL) and internal training courses.

Magnetic Resonance Imaging (MRI)

IRM/SRM 7T (Bruker)

ENI - Oncopôle

  • High-resolution anatomical imaging
  • Functional imaging
  • Spectroscopic analysis (SRM)

Nuclear imaging with PET, SPECT and CT

NanoScan PET/CT (Mediso)

ENI - Oncopôle

  • PET imaging [18F], [89Zr]

Static or dynamic acquisition, quantification (%ID, %ID/g, SUV, etc.), atlas repositioning

  • Anatomical imaging

Imaging of the skeleton and dentition, detection of pulmonary metastases by CT imaging and thresholding

NanoSPECT/CT (Bioscan)

ENI - Oncopôle

  • Functional imaging
  • SPECT imaging [99mTc], [111In], [123I], [201Tl]

Imagerie Ultrasonore

Aixplorer (Ultrasonic imaging)

ENI - Oncopole

  • Anatomical imaging:

Applications in oncology (detection and monitoring of tumor growth)

  • ShearWaveTM Elastography

Real-time visualization and analysis of tissue hardness, which assist in the early detection of lesions in a homogeneous organ.

Vevo2100 (Visualsonics) - High-resolution ultrasound scanner designed for small animal imaging

ENI - Rangueil

  • Anatomical imaging:

cardiovascular, cancer, developmental biology

  • Cardiovascular functional imaging:

Longitudinal studies of cardiac remodeling, measurements of systolic and diastolic function, ejection fractions, strain

  • Flux study:

Color doppler et Pulse-Wave Doppler

Bioluminescence and fluorescence imaging

IVIS Spectrum (Perkin Elmer)

Purpan

  • Bioluminescence and fluorescence imaging
  • Longitudinal monitoring of physiological and pathological phenomena (tumor growth), as well as the study of cell migration in a simple, rapid, non-traumatic manner in living animals.

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